Dyazide (triamterene and hydrochlorothiazide):
|Dyazide||50 mg / 25 mg tab||SmithKine Beecham|
Dyazide® is an oral diuretic/antihypertensive drug, It containing a mix of the two commonly prescribed agents hydrochlorthiazide and triamterene. The hydrochlorothiazide component is a strong thiazide diuretic, noticeably increasing the rate of sodium excretion. The triamterene is a potassium sparing diuretic, increasing the rate water & sodium are excreted but interfering with the loss of potassium. This combination results in a pronounced diuretic effect without the calcium and potassium loss seen with thiazides alone. The need for potassium supplements is therefore (generally) eliminated with the use this preparation.
Clinically, these drugs are most commonly used to treat cases of edema and high blood pressure (hypertension). Athletes however, use them to shed subcutaneous water during bodybuilding competitions and for weight class adjustments in certain competitive sports. Bodybuilders in particular rely heavily on the definition that results when excess water is reduced. The highly defined, super hard and shredded look so common today is nearly impossible to achieve without diuretics. At the same time diuretics are the reason weight class competitors like wrestlers often appear much heavier during a meet than they do at the weigh-in. A considerable amount of bodyweight (in the form of water) can be removed with diuretic use, often resulting in a drop of one or more weight categories. The user of course will rehydrate after the weigh-in, and will be much heavier that his/her weight class dictates during competition. When everyone is expecting to be matched against someone considerably heavier than his or her class weight dictates, this method of cheating becomes almost mandatory for a ‘fair” competition.
Among athletes, Dyazide is considered a moderately effective diuretic for such purposes. The water loss is stronger than that of a potassium-sparing agent like Aldactone®, but much weaker than that seen with a loop diuretic like Lasix. It could be most closely compared to the effect seen when a thiazide like Hydrodiuril (hydrochlorthiazide) is used alone, but again without the same level of calcium and potassium loss. Dyazide is therefore used when one wants to receive a good diuretic effect without needing to worry much about potassium supplementation. The diuretic activity following a single dose is usually evident within one hour. It will reach peak effect at approximately 2 to 3 hours and taper off during the next 7 to 9 hours. The athlete will generally use this drug for only the four days prior to a competition, adjusting the dosage to elicit the best level of effect. Since it has a long lasting effect, it is generally administered only once per day. One tablet is usually taken the first thing in the morning with a meal, and the effect judged. The dosage is increased one tablet per day (for perhaps 2 or 3 days at most) until the user is noticing the proper water loss. It is generally thought much more advantageous to prepare the few days before a show instead of loading up on diuretics that morning. The difference between a highly defined physique and a flat smooth dehydrated look is most often just a slight adjustment in dosage.
There is little doubt that diuretic use poses the greatest risk to an athlete. The dangers of this practice are much more pronounced than that of steroids, and are usually the cause when an ambitious professional is sacrificed to drug use. These compounds are very powerful, and should be respected as such. One should be well aware of the many potential side effects associated with diuretics like Dyazide. Muscle cramps, weakness, dizziness, headache, dry mouth, rash, diarrhea, constipation and severe dehydration are all common occurrences. Symptoms of nausea and vomiting can be seen as well, often indicative of an electrolyte imbalance. Administering the drug only after meals can usually prevent nausea. In severe instances, dehydration has resulted in coma or death. Athletes often walk a fine line between obtaining an optimal show physique and severely dehydrating themselves. This is clearly a risky practice, one should be very cautious.
Counterfeits: Should be a safe buy.