elpolicia escribió:OK EL ESTUDIO ES VAGO, NO DICE FECHA, QUIEN LO REALIZO Y DONDE, SUSTANCIA USADA, CANTIDADES, Y SI ES EN HUMANOS O ANIMALES.????? O SEA NO ACLARA EL PUNTO....
ES MAS NO PONGO EN DUDA LO QUE YA DIJE Y DE ESO HAY MUCHA MAS BIBLIOGRAFIA QUE ESE SIMPLE ESTUDIO.
ES MAS FIJATE:ESTO ACLARA EL PUNTO DE QUE SI ES UN AGENTE DE PARTICION PERO NO DICE COMO TRABAJA.Both increased rate of protein synthesis and/or decreased protein degradation have been suggested as the mechanism of action of these compounds
LO DE LOS EFECTOS ES VERIDICO YO PARA VERLOS TENGO QUE TOMAR MAS DE 60 MCG DIARIOS DE CLEN LO QUE S MUCHO PARA LA MAYORIA YA DE 80 PARA ARRIBA SON DEMASIADO FUERTES. EL SALBUTANOL NO ES LO MISMO PARECE PERO EN ESTRUTURA NO LO ES POR AHI YO POSTEE LAS DIFERENCIAS DEJAME VER SI LO UBICO Y LO PONGO POR ACA, Y EL ECA NUNCA A DADO NI DARA RESULTADOS PARECIDO O SIMILARES A NINGUNO DE ESTOS QUIMICOS.
compañero policia!! si haces clic en el link veras que el estudio fue realizado en la universidad de HAWAII, en 1992
Te digo que la pagina es muy utilizada como base para fundamentar echos en debates de gran interes y conocimientos entre grandes (entre los que se encuentran anthony roberts, N.Montana, Ross, etc)
Te dejo un par de links de otros estudios interesantes relacionados con el uso del clembuterol
Changes in skeletal muscle gene expression following clenbuterol administration.
* Spurlock DM,
* McDaneld TG,
* McIntyre LM.
Department of Animal Sciences, Iowa State University, Ames, IA, USA. moodyd@iastate.edu
BACKGROUND: Beta-adrenergic receptor agonists (BA) induce skeletal muscle hypertrophy, yet specific mechanisms that lead to this effect are not well understood. The objective of this research was to identify novel genes and physiological pathways that potentially facilitate BA induced skeletal muscle growth. The Affymetrix platform was utilized to identify gene expression changes in mouse skeletal muscle 24 hours and 10 days after administration of the BA clenbuterol. RESULTS: Administration of clenbuterol stimulated anabolic activity, as indicated by decreased blood urea nitrogen (BUN; P < 0.01) and increased body weight gain (P < 0.05) 24 hours or 10 days, respectively, after initiation of clenbuterol treatment. A total of 22,605 probesets were evaluated with 52 probesets defined as differentially expressed based on a false discovery rate of 10%. Differential mRNA abundance of four of these genes was validated in an independent experiment by quantitative PCR. Functional characterization of differentially expressed genes revealed several categories that participate in biological processes important to skeletal muscle growth, including regulators of transcription and translation, mediators of cell-signalling pathways, and genes involved in polyamine metabolism. CONCLUSION: Global evaluation of gene expression after administration of clenbuterol identified changes in gene expression and overrepresented functional categories of genes that may regulate BA-induced muscle hypertrophy. Changes in mRNA abundance of multiple genes associated with myogenic differentiation may indicate an important effect of BA on proliferation, differentiation, and/or recruitment of satellite cells into muscle fibers to promote muscle hypertrophy. Increased mRNA abundance of genes involved in the initiation of translation suggests that increased levels of protein synthesis often associated with BA administration may result from a general up-regulation of translational initiators. Additionally, numerous other genes and physiological pathways were identified that will be important targets for further investigations of the hypertrophic effect of BA on skeletal muscle.
PMID: 17181869 [PubMed - indexed for MEDLINE]
Fecha: 20 Diciembre 2006
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
Nifedipine does not impede clenbuterol-stimulated muscle hypertrophy.
* Murphy RJ,
* Beliveau L,
* Gardiner PF,
* Calderone A.
Departement de Kinesiologie, Universite de Montreal, Montreal, Canada H3C 3J7.
The mechanism(s) responsible for beta2-adrenergic receptor-mediated skeletal muscle and cardiac hypertrophy remains undefined. This study examined whether calcium influx through L-type calcium channels contributed to the development of cardiac and skeletal muscle (plantaris; gastrocnemius; soleus) hypertrophy during an 8-day treatment with the beta2-adrenergic receptor agonist clenbuterol. Concurrent blockade of L-type calcium channels with nifedipine did not reverse the hypertrophic action of clenbuterol. Moreover, nifedipine treatment alone resulted in both cardiac and soleus muscle hypertrophy (6% and 7%, respectively), and this effect was additive to the clenbuterol-mediated hypertrophy in the heart and soleus muscles. The hypertrophic effects of nifedipine were not associated with increases in total beta-adrenergic receptor density, nor did nifedipine reverse clenbuterol-mediated beta-adrenergic receptor downregulation in either the left ventricle or soleus muscle. Both nifedipine and clenbuterol-induced hypertrophy increased total protein content of the soleus and left ventricle, with no change in protein concentration. In conclusion, our results support the hypothesis that beta2-adrenergic receptor agonist-induced muscle hypertrophy is mediated by mechanisms other than calcium influx through L-type calcium channels.
PMID: 10404034 [PubMed - indexed for MEDLINE]
Fecha: Julio 1999
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
Seria interesante aclarar la forma de trabaja.. ya que sabemos que trabaja el clembuterol, y ayuda en general para salir
Policia, lo que mencionas en tu caso de que necesitas dosis elevadas, es dependiendo la persona, en tu caso es asi, pero conozco a personas que solo con 2 pastillas ya notan los efectos (los buenos y los malos tambien)
Si puedes, mencioname algun libro, o lugar de referencia para estudiar el asunto de como funciona... ya que me atrae mucho el tema de investigar este tipo de cosas
MI HERMANO A LEER BIEN AMBOS ESTUDIOS FUERON REALIZADOS EN ANIMALES 
Noticias
Site map
SitemapIndex
RSS Feed
