Evitar problemas con HCG y celulas de leyding

El tamoxifeno bloquea la desensibilizacion de las celulas de Leyding causada por HCG

La desensiblizacion de las celulas de leyding por parte del HCG es un gran tema. Aca hay un par de estudios que muestran que el uso del tamoxifeno puede ayudar en este tema.

El primer abstracto de un estudio, sugiere que el HCG bloquea la conversion de la 17-alfa-hidroxiprogesterona (17OPH), un precursos de la testosterona, a testosterona. Y este efecto es suprimido por el tamoxifeno

El segudo abstracto de un estudio, indica al parecer que el estrogeno no es el unico culpable, puesto que el tamoxifeno mas el HCG no aumenta los niveles de testosterona mas que la administracion del HCG solamente, aun cuando la combinacion reduce la desensibilizacion

Debido a que estamos intentando evitar la desensibilizacion, cuando detenemos la aplicacion de HCG los testiculos responden a nuestra LH endogena, esto le da sentido al usar siempre tamoxifeno junto con HCG para ayudar en el problema, si es que no se soluciona totalmente

J Clin Endocrinol Metab 1980 Nov;51(5):1026-9

tamoxifen suppresses gonadotropin-induced 17 alpha-hydroxyprogesterone accumulation in normal men.

Smals AG, Pieters GF, Drayer JI, Boers GH, Benraad TJ, Kloppenborg PW.

Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). These data indirectly suggest that, in man, the hCG-induced steroidogenic lesion might be mediated through its estrogen-stimulating effect.

Andrologia 1991 Mar-Apr;23(2):109-14

Effect of an antiestrogen on the testicular response to acute and chronic administration of hCG in normal and hypogonadotropic hypogonadic men: tamoxifen and testicular response to hCG.

Levalle OA, Suescun MO, Fiszlejder L, Aszpis S, Charreau E, Guitelman A, Calandra R.

Division Endocrinologia, Hospital Carlos Durand, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina.

The effect of the antiestrogen tamoxifen (Tx) on the acute and chronic hCG administration was evaluated in patients with hypogonadotropic hypogonadism (HH) and in normal men. An hCG test (5000 IU hCG) was performed before, after two months of hCG administration (2000 IU hCG three times weekly) and after two months of hCG + Tx (2000 IU hCG three times weekly plus 20 mg/day of tamoxifen). Blood samples were obtained before and following 24 and 72 h of every test to determine T, E, 17OHP and SHBG. T increased only in HH with both treatments (X +/- SEM: Basal: 97.9 +/- 19.7; hCG: 237.7 +/- 43.2; hCG +/- Tx: 204.7 +/- 10.7 ng/100 ml). 17OHP rose with hCG alone, but not with hCG + Tx in both groups. E, SHBG and 17OHP/T ratio did not change after treatments. hCG tests: E increased 24 h following hCG administration in every test. The ratio 17OHP/T rose at 24 h in the first and second test but in the third test it did not change. These results support the role of E in the acute hCG-induced Leydig cell desensitization. However, the association of Tx does not improve T serum levels, suggesting that E might not be the unique factor involved in the mechanisms for testicular desensitization.


Articulo por Karl Hoffman de Cutting Edge Muscle

Interesante amigo j.c. gracias por el aporte.